Piraeus is the seaport for Athens, the capital of western civilization, which boasts a fantastic mix of classical ruins and vivacious modern life. In a single day, you can climb the hill of the Acropolis to wonder at the Parthenon, join the lively Athenians in Constitution Square, and then find a welcoming taverna for some spirited bizouki music, plenty of ouzo to drink, and with luck, energetic Greek dancing.

With its steep volcanic flanks looming straight up from the sea, and the tiny white village of Thira clinging high atop the cliffs, Santorini is perhaps the most breathtaking and legendary of all the Greek Isles. To the south is Akrotiri, where recent Minoan excavations support the theories that Santorini might be the fabled lost continent of Atlantis.

Though once ruled by Venetian doges, Turkish sultans and French invaders, today's Corfiot citizen is as Greek as they come. Marvel at the 17th-century icons in St. George's Church, the medieval Palace of Phrourio or the 19th-century Achilleion Palace. The greenest of the Greek Isles, Corfu also boasts thriving vineyards and olive orchards among its rugged mountains.

The setting for Shakespeare's Much Ado About Nothing, Messina has much to offer in the way of history. Its dramatic, boulder-filled harbor has challenged navigators since the days of Ulysses. Try to visit the city's Bell Tower at the stroke of noon--the hour when one of the world's largest and most fanciful mechanical clocks springs into action. Messina's museum is also noteworthy for its Renaissance masterworks.

Barcelona is the cultural heartland of Spain, yet its first language is Catalan, the native tongue of the proudly independent Catalonia region. Stroll down the shady, tree-lined Ramblas between street musicians and elegant bistros. Then perhaps visit the venerable Gothic cathedral, Picasso Museum or enjoy the architectural genius of Antonio Gaudi's Church of the Holy Family.