The port of Civitavecchia is the gateway to The Eternal City, where all roads lead. Mad traffic careens past monuments of the great civilizations of the past. You will want to see it all: the soaring inspiration of St. Peter's, the Vatican and the Sistine Chapel; the flow of life along the Spanish Steps, the Coliseum, the Via Veneto and Trevi Fountain. Be sure to leave time for la dolce vita in one of the piazzas.

One of the most spectacular bays in the world lies in the shadow of Mt. Vesuvius. Visit the San Carlo Opera House and the cathedral of San Janarious, or tour the ancient ruins in the Roman cities of Pompeii and Herculaneum.

Once called Constantinople, the former capital of the Byzantine Empire is the only city in the world to straddle two continents: Europe and Asia. This is the Golden Horn, the door between East and West, and your first vision of its domes and minarets is unforgetable. Hagia Sophia, the Blue Mosque and Sultan treasures in Topkapi Palace await - as does the Grand Bazaar, laden with carpets, beaten brass and spices from afar.

The narrow passageways of Mykonos are a twisted maze of whitewashed houses, miniature churches, lazy windmills, and tiny cafes serving up Greek specialties. Sample the freshest squid or lobster just snatched from the blue Aegean Sea, or shop for typical flokati rugs.

Piraeus is the seaport for Athens, the capital of western civilization, which boasts a fantastic mix of classical ruins and vivacious modern life. In a single day, you can climb the hill of the Acropolis to wonder at the Parthenon, join the lively Athenians in Constitution Square, and then find a welcoming taverna for some spirited bizouki music, plenty of ouzo to drink, and with luck, energetic Greek dancing.

Though once ruled by Venetian doges, Turkish sultans and French invaders, today's Corfiot citizen is as Greek as they come. Marvel at the 17th-century icons in St. George's Church, the medieval Palace of Phrourio or the 19th-century Achilleion Palace. The greenest of the Greek Isles, Corfu also boasts thriving vineyards and olive orchards among its rugged mountains.

The setting for Shakespeare's Much Ado About Nothing, Messina has much to offer in the way of history. Its dramatic, boulder-filled harbor has challenged navigators since the days of Ulysses. Try to visit the city's Bell Tower at the stroke of noon--the hour when one of the world's largest and most fanciful mechanical clocks springs into action. Messina's museum is also noteworthy for its Renaissance masterworks.

Barcelona is the cultural heartland of Spain, yet its first language is Catalan, the native tongue of the proudly independent Catalonia region. Stroll down the shady, tree-lined Ramblas between street musicians and elegant bistros. Then perhaps visit the venerable Gothic cathedral, Picasso Museum or enjoy the architectural genius of Antonio Gaudi's Church of the Holy Family.